| lastfirst | TM | pos | GenPos | HT | WT | BirthDate | College | Salary |
| Benford, Christian | BUF | CB | DB | 6-1 | 205 | 9/21/2000 | Villanova | $0 |
| Elam, Kaiir | BUF | CB | DB | 6-2 | 195 | 5/5/2001 | Florida | $0 |
| Hamlin, Damar | BUF | S | DB | 6-1 | 200 | 3/24/1998 | Pittsburgh | $0 |
| Hyde, Micah | BUF | S | DB | 6-0 | 197 | 12/31/1990 | Iowa | $3,950,000 |
| Ingram, JaMarcus | BUF | CB | DB | 6-2 | 190 | 9/2/1997 | Utah St.,Texas Tech,Buffalo | $0 |
| Jackson, Dane | BUF | CB | DB | 5-11 | 180 | 11/29/1996 | Pittsburgh | $0 |
| Johnson, Jaquan | BUF | S | DB | 5-10 | 191 | 11/13/1995 | Miami (FL) | $495,000 |
| Johnson, Taron | BUF | CB | DB | 5-11 | 192 | 7/27/1996 | Weber St. | $570,000 |
| Lewis, Cameron | BUF | CB | DB | 5-9 | 185 | 4/13/1997 | Buffalo | $0 |
| Marlowe, Dean | BUF | S | DB | 6-1 | 208 | 7/25/1992 | James Madison | $645,000 |
| Neal, Siran | BUF | CB | DB | 6-0 | 206 | 8/4/1994 | Jacksonville St. | $570,000 |
| Poyer, Jordan | BUF | S | DB | 6-0 | 191 | 4/25/1991 | Oregon St. | $2,950,000 |
| White, Tre'Davious | BUF | CB | DB | 5-11 | 192 | 1/16/1995 | LSU | $1,382,374 |